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Navigating the Midlife Shift: How Gut Health Impacts Women Over 40

  • Writer: Kim Samari
    Kim Samari
  • Aug 17, 2025
  • 4 min read
A woman with hands over her belly

Ever feel like your body is a bit off since you hit 40? You're not alone. As a health coach, I see it all the time. The hormonal roller coaster of peri and post menopause can throw a wrench into everything, and one of the biggest—and most overlooked—areas is your gut health. It's not just about bloating or an upset stomach; a happy gut is the foundation for everything else, from your energy levels to your mood.


Hormones and Your Gut


The gut microbiome, home of trillions of bacteria, is a key player in everything from digesting food to managing your immune system. And guess what? Your hormones, especially estrogen, have a direct impact. As your estrogen levels go up and down and eventually decline, it can mess with the balance of your gut bacteria. This imbalance, called dysbiosis, can lead to a less diverse and less helpful community of microbes, which can trigger everything from digestive issues to widespread inflammation to anxiety and depression.


It's Not Just Your Hormones


While those hormonal shifts are a big deal, they're not the only culprits behind poor gut health. Our modern lives are full of things that can throw your gut out of whack:

  • Your Diet: A steady diet of processed foods, sugar, and unhealthy fats starves the good bacteria and feeds the bad ones.

  • Stress: Chronic stress puts your body in a constant state of fight-or-flight, which can slow down digestion and make your gut more permeable, or "leaky."

  • Sleep Deprivation: Not getting enough Z's is a surefire way to upset your gut's delicate balance. But it's a two-way street: a happy gut helps you sleep better, and good sleep helps your gut stay healthy.

  • Antibiotics: While sometimes necessary, they can be a bit like a bomb going off in your gut, wiping out the good guys along with the bad. It can take months to recover and get back to a healthy gut. For some people, it can be 6 months or longer!


The Gut-Brain Axis: Your Second Brain


This is where things get really interesting. Your gut and your brain are in constant communication via something called the gut-brain axis. Your gut even produces a huge portion of your body's serotonin—that "feel-good" hormone. So when your gut is unhappy, it can directly affect your mood, anxiety levels, and even how well you think.

Poor gut health can be the root cause of many seemingly unrelated health issues. When your gut is inflamed or leaky, it can trigger a domino effect of inflammation throughout your body, which has been linked to everything from autoimmune diseases to heart problems.


Research Shows: It's All Connected


The science is backing this up. Studies have shown a clear link between hormonal changes and gut bacteria. For example, research published in Cell Host & Microbe showed that fluctuations in estrogen in mice significantly changed their gut microbiome. Another study in the Journal of Psychiatric Research found a strong correlation between gut bacteria and symptoms of anxiety and depression.


A Health Coach's Secret Weapon


As a health coach, focusing on gut health is my starting point for almost every client, especially women over 40. So many seemingly unrelated symptoms—fatigue, brain fog, skin issues, mood swings—can be traced back to an unhappy gut.


More Than Just a Probiotic


Let's be real: simply popping a probiotic pill isn't going to fix everything. While they can be helpful for repopulating your gut with good bacteria, they're not a magic bullet. For real, lasting change, you have to look at your lifestyle habits.


We'll work together on both long-term short-term goals. We'll start by making simple changes to your sleep routine and diet. We'll focus on things like adding more fiber-rich foods to your meals and incorporating some fermented foods, while reducing processed foods and sugars. And of course, we will include some simple stress management techniques.


The best part? When we start with the gut, everything else falls into place. Clients start to feel more energetic, their digestion improves, they sleep better, and their mood stabilizes. Feeling better has a ripple effect. This makes them more active and able to exercise consistently. And guess what? Exercise, especially strength training, also benefits your gut. It strengthens the gut barrier, making it less permeable or "leaky," which further supports your overall gut health. It's amazing to see how healing one area of your health can positively impact your entire life.


Ready to start feeling great again? Let's take a look at your gut health and get you on the path to more energy and vitality.


References


  1. Houttu, N., et al. "Estrogen and the gut microbiome: a systematic review of the literature." Cell Host & Microbe, vol. 27, no. 4, 2020, pp. 544-554.

  2. Foster, J. A., et al. "The gut-brain axis: evidence for a role of the gut microbiota in anxiety and depression." Journal of Psychiatric Research, vol. 56, 2016, pp. 106-118.

  3. Sleep and the Microbiome: a two-way street. Nature Reviews Endocrinology (n.d.).

  4. Leaky Gut: What it is, how it affects your health, and what to do about it. Harvard Medical School. (2021).

 
 
 

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